Former Olympic bronze medallist Kipsang, 33, will be competing in his first marathon since he was forced to retire with exhaustion in the world athletics championships in Beijing.
"My training has been going on very well, and I hope to run a good race in New York," Kipsang told AFP before his departure for the US.
"I hope the weather will be more favourable than in Beijing, where the conditions were too hot and humid for my liking. I like running in New York City...I think the roads suit me very well."
Former world record holder Kipsang is a favourite to win the men's race.
But Keitany faces the biggest challenge to retain her crown against a strong field that includes the London marathon reigning champion, Tigist Tufa, who beat her into second place in the British capital last April.
