Dean Elgar will captain the side in the absence of Faf du Plessis, who is awaiting the birth of his first child.
This is the only match opportunity for the squad ahead of the first test match against England starting at Lord’s in London on July 6.
The majority of the squad has been in action with either the limited-overs squads or South Africa ‘A’, which opens up the opportunity to build a competitive edge against quality opposition.
“We have to compete,” Elgar said in Worcester on Wednesday.
“We have to compete against a very good England Lions side. To get that competitive edge will be a big thing for us. Naturally the guys will have that instinct in them so we have an important three days, weather permitting.
