The starting team boasts a combined total of 880 Test caps, eclipsing the previous most experienced side of 836 caps, which played in the Springboks’ last Rugby World Cup match against Australia in New Zealand in 2011.
The selection shows six changes from the side that beat Argentina in Buenos Aires a month ago.
De Villiers’ inclusion at inside centre is the only change to the backline, while Francois Louw returns at the side of the scrum.