With Leicester flailing in midtable, having won three of their opening nine games, and Spurs having drawn their last two league encounters, both will crave a morale-boosting victory in north London.
For Mauricio Pochettino's Spurs, who sit fifth in the table but just one point off the summit, victory will refuel a title challenge that has stuttered with draws to West Bromwich Albion and Bournemouth in their last two league matches.
A defeat to Liverpool, albeit with a much-changed side, in the League Cup fourth round on Tuesday, left them without a win since the start of the month when their title credentials looked rock solid after a 2-0 home victory over Manchester City.
For Claudio Ranieri's champions, Saturday's encounter will give them an opportunity to win back-to-back Premier League games for the first time since April and fire up a title defence that has looked forlorn in the opening months of the season.
Heavy defeats to Chelsea, Manchester United and Liverpool, added to a narrow opening-day loss to Hull City, have left them nine points off the pace and looking a shadow of the side that relentlessly pursued wins against the odds last season.
When the two sides last met in league at White Hart Lane in January, Leicester's 1-0 victory, courtesy of Robert Huth's late header, was seen as a sign that Ranieri's side had the mettle and stomach for a title challenge.
