Bethany Firth, Jonathan Fox and Steph Slater, who missed last summer's World Championships because of injury, return to the international scene.
The competition takes place from 30 April-8 May in Funchal, Madeira.
The GB team also includes Paralympic champions Ollie Hynd, Jessica-Jane Applegate and Josef Craig, as well as world champions Tully Kearney and Hannah Russell.
However, a number of GB swimmers, including Ellie Simmonds and Sascha Kindred, have not been included as the event comes straight after the Rio Paralympic trials, which take place in Glasgow from 23-27 April.
