"There was one performance this year that stunned me," Streep, 67, said as she was honored with the Cecil B. DeMille lifetime achievement award Sunday night.
"It sank its hooks in my heart. Not because it was good. It was that moment when the person asking to sit in the most respected seat in our country imitated a disabled reporter."
The three-time Oscar winner was referring to a 2015 incident at a South Carolina rally when Trump flailed his arms and slurred in his speech in an apparent mocking of New York Times reporter Serge Kovaleski, who has a physical disability. Trump later denied that he was imitating the reporter.