A day after the bombshell news surrounding the world's richest female athlete -- the five-time grand slam winner's estimated net worth is $195 million -- we answer five key questions in the case.
The complexity of cases is a factor, as is the evidence that needs to be examined.
However, there is a way for the four-year suspension to be reduced, if it is established that the anti-doping rule violation wasn't intentional. In that case, the most likely ban is two years.
The World Anti-Doping Agency (WADA), which formulates the list of banned substances followed by major sports bodies around the world, didn't have it on its prohibited list prior to 2016.
Why was it added this year, then, under metabolic modulators?
"Meldonium was added (to the prohibited) list because of evidence of its use by athletes with the intention of enhancing performance," WADA said on its website.
It may boost endurance and aid in the recovery process.
Another website, cleancompetition.org, revealed last October the results of a research project it partly funded which found 182 or 2.2% of 8,300 urine samples collected from athletes contained mildronate, also known as meldonium.
"This figure represents more than twice the overall rate of laboratory findings for a single drug than any of the substances on the Prohibited List."
That Sharapova didn't check the updated list raised eyebrows. More surprising is the fact that, according to her lawyer John Haggerty, no one on her team did, either.
"Unfortunately no one from Maria's team looked at the 2016 banned list but had they done so they would have looked for mildronate and not found it on the list," Haggerty wrote in an email to CNN.